CLEVELAND, Ohio — The Guardians played to a 4-4 tie on Saturday after Chris Roller scored on a wild pitch in the eighth inning by Oakland’s Drew Steckenrider. Cleveland’s Cactus League record entering play on Sunday is 4-4-1 as Triston McKenzie gets ready for his second exhibition start.

Manager Terry Francona’s lineup against the Diamondbacks includes a familiar first four of Steven Kwan, Amed Rosario, Jose Ramirez and Josh Bell as well as All-Star second baseman Andres Gimenez and projected starting catcher Mike Zunino. Prospect Micah Pries, who is swinging a hot bat after picking up his second home run of the spring on Saturday is also in the lineup. Center fielder Myles Straw will make his second start after being delayed by a sore right knee.

Consulted source https://www.cleveland.com/

At least 5 people shot at San Pedro beach

At least five people were injured in a shooting Saturday night at a San Pedro beach, authorities said.

Police received a call at 5:44 p.m. reporting gunfire at Royal Palms Beach near Paseo del Mar and Graysby Avenue, said Lt. Sharon Brady with the Los Angeles Police Department’s Harbor Community Police Station.

Brady said four people who had been shot were taken to local hospitals by emergency personnel.

consulted source https://www.latimes.com/

Kourtney Kardashian is proving blonds really do have more fun.

The “Kardashians” star, who is naturally brunette, took to Instagram on Saturday to unveil her new ‘do – a chic platinum blond bob.

The Poosh founder, rocking a leather lace-up corset with a matching jacket, shared three pics of herself showing off the lighter locks. Kardashian, 43, completed her look with bold eye makeup and a silver statement necklace.

Consulted source https://pagesix.com/

The reality TV star, who secretly welcomed her first child with boyfriend musician Sid Wilson, 45, in recent months, already returned to work on the family’s new series “Home To Roost” after baby Sidney’s arrival.

And it seems as though her brother, Jack Osbourne, is already somewhat of a pro at uncle-ling.

“An uncle is a blessing. It means so many things. Words could never tell the joy an uncle brings,” Kelly captioned the snap of her son with Jack, 37, with an Irene Banks quote.

“An uncle is a bond of faith that even time can’t sever, a gift to last all of our lives. An uncle is forever.”

consulted source https://pagesix.com/

Alex Murdaugh shaves head for new mugshot after receiving double life sentence for murder of wife, son

Convicted murderer Alex Murdaugh shaved his head for his newest mugshot, hours after he was handed two consecutive life sentences for killing his wife and son.

The disgraced former lawyer, who kept his distinctive red hair for most of his murder trial, stares coldly ahead while wearing a yellow jumpsuit in the latest mugshot, snapped after he was booked Friday at South Carolina’s Kirkland Reception and Evaluation Center.

consulted source https://nypost.com/

One in five Americans will experience major depressive disorder in their lifetime, and many will not find relief from current therapies. But now researchers have identified an unexpected source of the problem: inflammation.

Inflammation in the body may be triggering or exacerbating depression in the brains of some patients. And clinical trial data suggests that targeting and treating the inflammation may be a way to provide more-precise care.

The findings have the potential to revolutionize medical care for depression, an often intractable illness that doesn’t always respond to conventional drug treatments. While current drug treatments target certain neurotransmitters, the new research suggests that in some patients, depressive behaviors may be fueled by the inflammatory process.

It appears that inflammatory agents in the blood can break down the barrier between the body and the brain, causing neuroinflammation and altering key neural circuits, researchers say. In people at risk for depression, inflammation may be a trigger for the disorder.

Research suggests that only a subset of depressed patients — roughly 30 percent — have elevated inflammation, which is also associated with poor responses to antidepressants. This inflammatory subgroup may be a key to parsing out differences in underlying mechanisms for depression and personalizing treatment.

“Activation of these inflammatory pathways in the body and brain is one of the ways through which depressive symptoms can be produced,” said Charles Raison, a professor of human psychology, human ecology and psychiatry at the University of Wisconsin at Madison.

Source consulted "https://www.washingtonpost.com/